Structure of PDB 3w3j Chain B

Receptor sequence
>3w3jB (length=746) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSYPCDEKKQVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESF
QGLQNLTKINLNHNPNVGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLP
ESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDG
VFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGL
INLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS
STSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLS
FNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPN
LSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPFEFDPHSNFYHFT
RPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVL
SGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA
GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLD
ILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHI
NDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH
NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHG
NPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL
3D structure
PDB3w3j Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C09 B Y348 Y353 V378 F405 Y303 Y308 V333 F360
BS02 C09 B D543 D545 G572 V573 T574 D472 D474 G501 V502 T503
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w3j, PDBe:3w3j, PDBj:3w3j
PDBsum3w3j
PubMed23520111
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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