Structure of PDB 3w0l Chain B

Receptor sequence
>3w0lB (length=598) Species: 8355 (Xenopus laevis) [Search protein sequence]
TRKYQHVIETPDPGKWELAGYEESLPISEKSNPMTRELDKADPSQLVQLL
RDCDAEIFQEEDENLIHYHRLYSESVLKTMGDVAKRVQEVLKNPDDSLVV
LSGCGTSGRLALLLANSFNGLLKGLHKTPCYCYIMSGGDRSIVTSQESSE
DNPQLGAQELEKVCEGKKNVLFIGISCGLSAPFIAGQLDFCMRHLDVYLP
VLVGFNPVSMARNERIEGWHSSFRQVAERLQTLHDSQKGFILNPAVGPEG
VSGSSRMKGGSATKILLETLLLVAHKAEVTEKCLLEILRTYERAHKVTYS
QSKKIAALMKQTATSLQKKGHLYILGWGTLGLVGIMDAVECVPTYQADWR
DVRGFITGGYHSIENKEGDLSSLGPQFSISHEDFVKNVLPSVSETDTVLL
IFTLDDDLNQIEKLVALVKEKTSNIQVICHATAGQYLPNSLKKTIPSIIG
LTWPILFLEYEGAFIQKFQRELSTKWILDTVTSGAYTLRGKIFRNFMVDF
KINNSKLFHRATSVLQRLTGQSQQRCTEVLLQSIYGEQTLSEQIRNTTIA
GHVEAAASQDKVLPVAIVSLLRSCTIQDSRSRINSSLSIRSAIESSMN
3D structure
PDB3w0l Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase
ChainB
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6R B C107 G108 T109 S179 C180 R259 E347 K513 C104 G105 T106 S176 C177 R256 E340 K506 PDBbind-CN: -logKd/Ki=7.02,Kd=95nM
Gene Ontology
Molecular Function
GO:0004857 enzyme inhibitor activity
GO:0019899 enzyme binding
GO:0030246 carbohydrate binding
GO:0070095 fructose-6-phosphate binding
GO:0097367 carbohydrate derivative binding
Biological Process
GO:0009750 response to fructose
GO:0033132 negative regulation of glucokinase activity
GO:0042593 glucose homeostasis
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w0l, PDBe:3w0l, PDBj:3w0l
PDBsum3w0l
PubMed23733961
UniProtQ91754|GCKR_XENLA Glucokinase regulatory protein (Gene Name=gckr)

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