Structure of PDB 3vzv Chain B

Receptor sequence
>3vzvB (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB3vzv Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VZV B L54 M62 Y67 Q72 V93 H96 I99 L30 M38 Y43 Q48 V69 H72 I75
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3vzv, PDBe:3vzv, PDBj:3vzv
PDBsum3vzv
PubMed23266121
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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