Structure of PDB 3vs7 Chain B

Receptor sequence
>3vs7B (length=427) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGS
YSLSVRDYDPRQGDTVKHYKIRTFYISPRSTFSTLQELVDHYKKGNDGLC
QKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH
TKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITE
FMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRA
ANILVSASLVCKIADFGLARPIKWTAPEAINFGSFTIKSDVWSFGILLME
IVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE
ERPTFEYIQSVLDDFYTATESQYEEIP
3D structure
PDB3vs7 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
ChainB
Resolution3.001 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D297 R299 A301 N302 D315
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KS1 B V281 T338 F340 M341 S345 L393 A403 D404 V192 T249 F251 M252 S256 L304 A314 D315
BS02 CA B E524 Y527 E528 E529 E420 Y423 E424 E425
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3vs7, PDBe:3vs7, PDBj:3vs7
PDBsum3vs7
PubMed23596204
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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