Structure of PDB 3vs3 Chain B

Receptor sequence
>3vs3B (length=432) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGS
YSLSVRDYDPRQGDTVKHYKIRTFYISPRSTFSTLQELVDHYKKGNDGLC
QKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH
TKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITE
FMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRA
ANILVSASLVCKIADFGLARVIEKFPIKWTAPEAINFGSFTIKSDVWSFG
ILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCW
KNRPEERPTFEYIQSVLDDFYTATESQYEEIP
3D structure
PDB3vs3 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
ChainB
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D297 R299 A301 N302 D315 F325
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VSE B L273 V281 A293 K295 V323 L325 T338 M341 S345 D348 L393 D404 F405 L184 V192 A204 K206 V234 L236 T249 M252 S256 D259 L304 D315 F316 BindingDB: IC50=0.426580nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3vs3, PDBe:3vs3, PDBj:3vs3
PDBsum3vs3
PubMed23596204
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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