Structure of PDB 3vpo Chain B

Receptor sequence
>3vpoB (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
MGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEQVDLSKDIQ
HWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGF
QIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWI
GDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISR
DEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIG
MNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFM
3D structure
PDB3vpo Essential role of E106 in the proton-coupled electron transfer in human
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y176
Catalytic site (residue number reindexed from 1) Y112
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B R78 V81 T156 R14 V17 T92
BS02 FE B E169 E232 E266 H269 E105 E168 E202 H205
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3vpo, PDBe:3vpo, PDBj:3vpo
PDBsum3vpo
PubMed
UniProtP31350|RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (Gene Name=RRM2)

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