Structure of PDB 3vah Chain B

Receptor sequence
>3vahB (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQIN
QDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGAHKLF
IGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINV
TDQAIAGLNGMQLGDKKLLVQRAS
3D structure
PDB3vah U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R150 Y152 K195 F197 F199 K225 P229 H230 D231 R8 Y10 K53 F55 F57 K83 P87 H88 D89
BS02 rna B F262 G265 S294 K300 Y302 F304 Q333 F100 G103 S132 K138 Y140 F142 Q171
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:3vah, PDBe:3vah, PDBj:3vah
PDBsum3vah
PubMed23376934
UniProtP26368|U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (Gene Name=U2AF2)

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