Structure of PDB 3vaf Chain B

Receptor sequence
>3vafB (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
LGSARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQD
KNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGAHKLFIG
GLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTD
QAIAGLNGMQLGDKKLLVQRAS
3D structure
PDB3vaf U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
ChainB
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B F262 S294 K300 Y302 F304 L331 A335 F98 S130 K136 Y138 F140 L167 A171
BS02 rna B R150 Y152 K195 N196 F197 F199 K225 R227 P229 H230 D231 R6 Y8 K51 N52 F53 F55 K81 R83 P85 H86 D87
BS03 CPQ B Y269 L270 Q274 L325 G326 Y105 L106 Q110 L161 G162
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:3vaf, PDBe:3vaf, PDBj:3vaf
PDBsum3vaf
PubMed23376934
UniProtP26368|U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (Gene Name=U2AF2)

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