Structure of PDB 3v9h Chain B

Receptor sequence
>3v9hB (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]
RWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEE
VWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIA
DRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRF
NAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGA
PALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDT
VTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHF
VHRSADVESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEH
SRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCD
DSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDS
TTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGG
ARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ
3D structure
PDB3v9h The Three-Dimensional Structural Basis of Type II Hyperprolinemia.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N211 K233 E314 C348 E447 P532
Catalytic site (residue number reindexed from 1) N189 K211 E292 C326 E425 P510
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 B S349 G512 S513 S327 G490 S491
BS02 SO4 B R47 Q51 R25 Q29
Gene Ontology
Molecular Function
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
Biological Process
GO:0006560 proline metabolic process
GO:0006562 proline catabolic process
GO:0010133 proline catabolic process to glutamate
GO:0019470 4-hydroxyproline catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3v9h, PDBe:3v9h, PDBj:3v9h
PDBsum3v9h
PubMed22516612
UniProtP30038|AL4A1_HUMAN Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Gene Name=ALDH4A1)

[Back to BioLiP]