Structure of PDB 3v4v Chain B

Receptor sequence
>3v4vB (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
RGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEG
YPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDK
TVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQ
SVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGK
LGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVT
SAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSS
LPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCL
PEPHLLRLRALGFSEELIVELHTLC
3D structure
PDB3v4v Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S142 S144 E240 S62 S64 E160
BS02 CA B S144 D147 E354 S64 D67 E274
BS03 CA B D179 N235 D237 S238 P239 E240 D99 N155 D157 S158 P159 E160
BS04 0DU B S142 Y143 G234 N235 L236 D237 S238 S62 Y63 G154 N155 L156 D157 S158 PDBbind-CN: -logKd/Ki=7.38,IC50=42nM
BindingDB: IC50=42nM
External links
PDB RCSB:3v4v, PDBe:3v4v, PDBj:3v4v
PDBsum3v4v
PubMed22232704
UniProtP26010|ITB7_HUMAN Integrin beta-7 (Gene Name=ITGB7)

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