Structure of PDB 3v4k Chain B

Receptor sequence
>3v4kB (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
HSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLNQRRGFLAN
QAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQE
MAKFISKNKHVSLCIKTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFK
HCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQ
3D structure
PDB3v4k First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G.
ChainB
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E209 P210 H367 E15 P16 H173
BS02 ZN B H248 H250 H54 H56
BS03 ZN B H257 C288 C291 H63 C94 C97
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:3v4k, PDBe:3v4k, PDBj:3v4k
PDBsum3v4k
PubMed22181350
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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