Structure of PDB 3v3l Chain B

Receptor sequence
>3v3lB (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
GNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADL
ENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLD
3D structure
PDB3v3l Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V3L B R110 R161 R12 R63 MOAD: Kd~370nM
BS02 V3L B Y107 R110 W114 Y116 I139 Y144 Q153 R161 R163 K175 G179 Y9 R12 W16 Y18 I41 Y46 Q55 R63 R65 K77 G81 MOAD: Kd~370nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0072572 poly-ADP-D-ribose binding
Biological Process
GO:0016055 Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3v3l, PDBe:3v3l, PDBj:3v3l
PDBsum3v3l
PubMed22267412
UniProtQ9NTX7|RN146_HUMAN E3 ubiquitin-protein ligase RNF146 (Gene Name=RNF146)

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