Structure of PDB 3uzp Chain B

Receptor sequence
>3uzpB (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIGSGDIYLGTDIAAGEEVAIKLECVKTHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLAD
QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGS
LPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRF
DDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB3uzp Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
ChainB
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D118 K120
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0CK B I23 A36 K38 M80 M82 L85 L135 I148 I18 A31 K33 M70 M72 L75 L125 I138 BindingDB: IC50=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3uzp, PDBe:3uzp, PDBj:3uzp
PDBsum3uzp
PubMed22168824
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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