Structure of PDB 3uwq Chain B

Receptor sequence
>3uwqB (length=224) Species: 666 (Vibrio cholerae) [Search protein sequence]
DPKVIVALDYDNLADALAFVDKIDPSTCRLKVGKEMFTLFGPDFVRELHK
RGFSVFLDLKFHDIPNTCSKAVKAAAELGVWMVNVHASGGERMMAASREI
LEPYGKERPLLIGVTVLTSMESADLQGIGILSAPQDHVLRLATLTKNAGL
DGVVCSAQEASLLKQHLGREFKLVTPGIRPAGSQRRIMTPAQAIASGSDY
LVIGRPITQAAHPEVVLEEINSSL
3D structure
PDB3uwq 1.80 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase from Vibrio cholerae O1 biovar eltor str. N16961 in complex with uridine-5'-monophosphate (UMP)
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K33 D60 K62 D65 T120 R211
Catalytic site (residue number reindexed from 1) K31 D58 K60 D63 T118 R205
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P B A9 D11 K33 T120 P178 G179 R181 G210 R211 A7 D9 K31 T118 P176 G177 R179 G204 R205
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3uwq, PDBe:3uwq, PDBj:3uwq
PDBsum3uwq
PubMed
UniProtQ9KQT7|PYRF_VIBCH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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