Structure of PDB 3ur0 Chain B

Receptor sequence
>3ur0B (length=476) Species: 223997 (Murine norovirus 1) [Search protein sequence]
LPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKD
ERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQ
KPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMY
EMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGP
FCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQ
RAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSG
PCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLE
LDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGW
YGRLDRASIDRQLLWTKGPNHQNPFETLPGRPSQLMALLGEAAMHGEKYY
RTVASRVSKEAVVPRHRSVLRWVRFG
3D structure
PDB3ur0 Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SVR B P38 P39 G40 A41 W42 A409 R413 P37 P38 G39 A40 W41 A407 R411 MOAD: ic50=70nM
PDBbind-CN: -logKd/Ki=7.15,IC50=70nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3ur0, PDBe:3ur0, PDBj:3ur0
PDBsum3ur0
PubMed22446684
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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