Structure of PDB 3upo Chain B

Receptor sequence
>3upoB (length=435) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSST
ALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWD
AMQQGCYGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAW
QRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQLTAAPT
IPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGADAL
RSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTPLA
NAEIAATIANGGITMRPYLVGSLKGPDLANISTTVRYQQRRAVSPQVAAK
LTELMVGAEKVAQPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPK
VAVAVLVENGADRLSATGGALAAPIGRAVIEAALQ
3D structure
PDB3upo The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNM B S222 E259 Y261 S281 N283 T425 G426 T427 G472 S174 E211 Y213 S233 N235 T372 G373 T374 G419
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0016787 hydrolase activity
GO:0071972 peptidoglycan L,D-transpeptidase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3upo, PDBe:3upo, PDBj:3upo
PDBsum3upo
PubMed22365933
UniProtP9WKD1|PBPA_MYCTU Peptidoglycan D,D-transpeptidase PbpA (Gene Name=pbpA)

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