Structure of PDB 3upj Chain B

Receptor sequence
>3upjB (length=97) Species: 11709 (Human immunodeficiency virus 2) [Search protein sequence]
FSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGG
FINTLEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
3D structure
PDB3upj Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D23 T24 G25
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.47: HIV-2 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U03 B D25 I50 I84 D23 I48 I82
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3upj, PDBe:3upj, PDBj:3upj
PDBsum3upj
PubMed7658450
UniProtP04584|POL_HV2RO Gag-Pol polyprotein (Gene Name=gag-pol)

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