Structure of PDB 3up0 Chain B

Receptor sequence
>3up0B (length=242) Species: 53326 (Ancylostoma ceylanicum) [Search protein sequence]
SYQLNAAELQALDLIQEAFKGMNDPMEQGRQATSFLKNEKSPADIMNIMD
VTMRRFVKMAKRLPAFNDLSQDGKFALLKGGMIEMLTVRGVRRFDSSSGS
WTTPTLGESSEVSINMFDQLNADVRSEQKMRFLQFFKIFHEDIRSNDLVI
SMIMLIVLFSPRDSITDPEDRRIIARHHEQFSALLNRYLESLYGDDAHQL
NEQLPTALRMLREISASSGMLFLGTVNTSEAEPLPREFFKVE
3D structure
PDB3up0 Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K504 D515 K517 F518 K522 E680 K61 D72 K74 F75 K79 E237
BS02 D7S B M492 V494 T495 L529 T530 R532 T546 M559 F560 Q571 M49 V51 T52 L86 T87 R89 T103 M116 F117 Q128
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3up0, PDBe:3up0, PDBj:3up0
PDBsum3up0
PubMed22170062
UniProtH0USY8

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