Structure of PDB 3ukq Chain B

Receptor sequence

>3ukqB (length=510) Species: 746128 (Aspergillus fumigatus)

THPDISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDV
TPEGFLYDVGGHVIFSHYKYFDDCLDEALPKEDDWYTHQRISYVRCQGQW
VPYPFQNNISMLPKEEQVKCIDGMIDAALEARVANTKPKTFDEWIVRMMG
TGIADLFMRPYNFKVWAVPTTKMQCAWLGERVAAPNLKAVTTNVILGKTA
GNWGPNATFRFPARGGTGGIWIAVANTLPKEKTRFGEKGKVTKVNANNKT
VTLQDGTTIGYKKLVSTMAVDFLAEAMNDQELVGLTKQLFYSSTHVIGVG
VRGSRPERIGDKCWLYFPEDNCPFYKATIFSNYSPYNQPEASKKLPTMQL
ADGSRPQSTEAKEGPYWSIMLEVSESSMKPVNQETILADCIQGLVNTEML
KPTDEIVSTYHRRFDHGYPTPTLEREGALTQILPKLQDKDIWSRGRFGSW
RYEVGNQDHSFMLGVEAVDNIVNGAVELTLNYPDFVNGRQNTERRLVDGA
QVFAKSKAQL

3D structure

• PDB: 3ukq Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus.
• Chain: B
• Resolution: 3.15 Å

Enzymatic activity

• Enzyme Commision number: 5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G14 G16 P17 T18 D38 G45 L46 V60 H63 V242 G418 G446 R447 G456 N457 Q458 S461	G13 G15 P16 T17 D37 G44 L45 V59 H62 V241 G417 G445 R446 G455 N456 Q457 S460
BS02	GDU	B	Y104 F106 F158 M159 N163 R182 V183 N207 W315 K327 Y453	Y103 F105 F157 M158 N162 R181 V182 N206 W314 K326 Y452

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008767 UDP-galactopyranose mutase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0071555 cell wall organization

External links

• PDB: RCSB:3ukq, PDBe:3ukq, PDBj:3ukq
• PDBsum: 3ukq
• PubMed: 22334662
• UniProt: Q4W1X2|GLFA_ASPFM UDP-galactopyranose mutase (Gene Name=glfA)