Structure of PDB 3uj0 Chain B

Receptor sequence
>3uj0B (length=502) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SSFLHIGDIASLYAEGSTNGFISTLGLVDDRAVVQPEAGDLNNPPKKFRD
ALFKLAPMNRYSAQKQFWKASTTDAVLLNKLHHAADLEKKQNETENRKLL
GTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWF
YIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNGANEVNSV
NANTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTADEHRKKQHV
FLRTTGRQSATSATSSKALWEVEVVQHDPARWNSLFRFKHLATGHYLAAE
VMVYSLVSVPEGNDISSIFELDPVPRNSYVRLRHLATNTWVHSTNIPIKE
EEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGK
LEKGTITQNERRSVTKLLEDLVYFVTGGTNSLEVVFSKPNRERQKLMREQ
NILKQIFKLLQAPFPFRHIARLAYRVLRHSQQDYRKNQEYIAKQFGFMQK
QI
3D structure
PDB3uj0 Structural and functional conservation of key domains in InsP3 and ryanodine receptors.
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3P B R265 T267 G268 R269 Y567 K569 R253 T255 G256 R257 Y484 K486 BindingDB: Kd=8.7nM,EC50=209nM
Gene Ontology
Molecular Function
GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006816 calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3uj0, PDBe:3uj0, PDBj:3uj0
PDBsum3uj0
PubMed22286060
UniProtP29994|ITPR1_RAT Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (Gene Name=Itpr1)

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