Structure of PDB 3ue4 Chain B

Receptor sequence
>3ue4B (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
DKWEMERTDITMKHKLGGGGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL
KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE
VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL
SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIAT
YGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRP
SFAEIHQAFETMFQESSI
3D structure
PDB3ue4 Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the abl tyrosine kinase domain.
ChainB
Resolution2.424 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147 P168
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DB8 B L248 A269 K271 I313 T315 M318 T319 G321 L370 F382 L16 A35 K37 I79 T81 M84 T85 G87 L136 F148 BindingDB: IC50=1.1nM,Kd=0.057000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ue4, PDBe:3ue4, PDBj:3ue4
PDBsum3ue4
PubMed22493660
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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