Structure of PDB 3udd Chain B

Receptor sequence
>3uddB (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRV
TLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEY
LITYQIMKPE
3D structure
PDB3udd [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1234 H1237 C1242 C1245 C130 H133 C138 C141
BS02 34M B H1184 S1186 P1187 F1188 A1191 I1192 K1195 F1197 D1198 H1201 Y1203 I1212 Y1213 Y1224 G1227 I1228 H80 S82 P83 F84 A87 I88 K91 F93 D94 H97 Y99 I108 Y109 Y120 G123 I124 BindingDB: Kd=79nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3udd, PDBe:3udd, PDBj:3udd
PDBsum3udd
PubMed22260203
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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