Structure of PDB 3u6b Chain B

Receptor sequence
>3u6bB (length=376) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAAKARGITIN
TSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMP
QTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFP
GDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLP
IEDVFSITVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDE
GRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGG
RHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIA
MDDGLRFAIREGGRTVGAGVVAKVLG
3D structure
PDB3u6b Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
ChainB
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D21 K24 T25 T61 H84
Catalytic site (residue number reindexed from 1) D20 K23 T24 T48 H71
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E215 D216 F218 V226 T228 T256 E259 F261 R262 N273 V274 G275 L277 E202 D203 F205 V209 T211 T239 E242 F244 R245 N256 V257 G258 L260
BS02 GDP B D21 G23 K24 T25 T26 N135 K136 D138 M139 S173 L175 D20 G22 K23 T24 T25 N122 K123 D125 M126 S160 L162
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032045 guanyl-nucleotide exchange factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3u6b, PDBe:3u6b, PDBj:3u6b
PDBsum3u6b
PubMed21999529
UniProtP0CE47|EFTU1_ECOLI Elongation factor Tu 1 (Gene Name=tufA)

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