Structure of PDB 3u15 Chain B

Receptor sequence
>3u15B (length=82) Species: 9606 (Homo sapiens) [Search protein sequence]
QVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVY
CGGDLLGELLGRQSFSVKDPSPLYDMLRKNLV
3D structure
PDB3u15 Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 03M B M53 G57 F90 V92 M28 G32 F65 V67 MOAD: Kd=0.078uM
PDBbind-CN: -logKd/Ki=7.11,Kd=0.078uM
BS02 03M B I60 M61 Y66 Q71 V92 I35 M36 Y41 Q46 V67 MOAD: Kd=0.078uM
PDBbind-CN: -logKd/Ki=7.11,Kd=0.078uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3u15, PDBe:3u15, PDBj:3u15
PDBsum3u15
PubMed22745160
UniProtO15151|MDM4_HUMAN Protein Mdm4 (Gene Name=MDM4)

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