Structure of PDB 3twv Chain B

Receptor sequence
>3twvB (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
3D structure
PDB3twv Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainB
Resolution2.301 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K557 W591 K621 R623 D624 G625 K70 W104 K134 R136 D137 G138
BS02 peptide B R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K604 R38 S40 F45 G48 Y49 L73 N78 Y82 H84 D102 W104 F106 E111 K117
External links
PDB RCSB:3twv, PDBe:3twv, PDBj:3twv
PDBsum3twv
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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