Structure of PDB 3twt Chain B

Receptor sequence
>3twtB (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIRQSTPLHFAAGYNRV
SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD
LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI
QDLLR
3D structure
PDB3twt Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L590 W591 K592 K621 R623 D624 L101 W102 K103 K132 R134 D135
BS02 peptide B R525 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K604 R36 F43 G46 Y47 L71 N76 Y80 H82 D100 W102 F104 E109 K115
External links
PDB RCSB:3twt, PDBe:3twt, PDBj:3twt
PDBsum3twt
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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