Structure of PDB 3ttz Chain B

Receptor sequence
>3ttzB (length=185) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
QVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEV
VIEKDNWIKVTDNGRGIPVDIQGRPAVEVILTSSVVNALSQDLEVYVHRN
ETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETL
QQRIRELAFLNKGIQITLRDERDEENVREDSYHYE
3D structure
PDB3ttz Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy.
ChainB
Resolution1.63 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 07N B N54 E58 D81 R84 G85 I86 P87 T173 N35 E39 D62 R65 G66 I67 P68 T128 MOAD: ic50=0.004uM
BindingDB: IC50=4nM
BS02 MG B G208 H228 G163 H183
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ttz, PDBe:3ttz, PDBj:3ttz
PDBsum3ttz
PubMed22041057
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

[Back to BioLiP]