Structure of PDB 3tlj Chain B

Receptor sequence
>3tljB (length=364) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
MKFLLTTAQGIEDIAKREVSLLLKKLGISFQIEEKPLGIEGRLLLEAEKA
YYVDEKGRKRELSISTYLNENSRLLHRVIIEIASEKFNGIEKDESEEALK
RIKDFVSSLPVEQFVKVSETFAVRSFRKGDHNITSIDIARTVGEAIFERL
SRFGTPLVNLDHPAVIFRAELIKDVFFLGIDTTGDSSLHKRPWRVYDHPA
HLKASIANAMIELAELDGGSVLDPMCGSGTILIELALRRYSGEIIGIEKY
RKHLIGAEMNALAAGVLDKIKFIQGDATQLSQYVDSVDFAISNLPYGSMI
PDLYMKFFNELAKVLEKRGVFITTEKKAIEEAIAENGFEIIHHRVIGHGG
LMVHLYVVKLEHHH
3D structure
PDB3tlj Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.256: tRNA (guanine(6)-N(2))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B H198 M225 C226 G227 S228 T230 E248 Y250 D276 A277 N293 H198 M225 C226 G227 S228 T230 E248 Y250 D276 A277 N293
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0016423 tRNA (guanine) methyltransferase activity
GO:0016740 transferase activity
GO:0160117 tRNA (guanine(6)-N2)-methyltransferase activity
Biological Process
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:3tlj, PDBe:3tlj, PDBj:3tlj
PDBsum3tlj
PubMed22362751
UniProtQ8U248|TRM14_PYRFU tRNA (guanine(6)-N2)-methyltransferase (Gene Name=trm14)

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