Structure of PDB 3tkw Chain B

Receptor sequence

>3tkwB (length=103) Species: 11686 (Human immunodeficiency virus type 1 (BRU ISOLATE))

SFNFPQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKM
IGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGAT
LNF

3D structure

• PDB: 3tkw Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.
• Chain: B
• Resolution: 1.55 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D29 T30 G31
• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	017	B	D25 G27 A28 D30 V82 I84	D29 G31 A32 D34 V86 I88	PDBbind-CN: -logKd/Ki=5.27,Kd=5.4uM

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:3tkw, PDBe:3tkw, PDBj:3tkw
• PDBsum: 3tkw
• PubMed: 22242794
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)