Structure of PDB 3thz Chain B

Receptor sequence
>3thzB (length=846) Species: 9606 (Homo sapiens) [Search protein sequence]
SKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYC
HLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSS
LFSRKLTALYTKSTLIGEDVNPTDTSTSYLLCISENKKKKGNIFIGIVGV
QPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRA
TSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKGIVNLEKPVICSLAA
IIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMK
TKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSES
SVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAI
IPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKD
LSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIE
IKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSA
EWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEER
KIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSY
IKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAAGRSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTH
YPPVCELEKNYSHQVGNYHMGFLVFVTFLYQITRGIAARSYGLNVAKLAD
VPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWT
3D structure
PDB3thz Mechanism of mismatch repair revealed by human MutS bound to unpaired DNA loops
ChainB
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B S216 T221 L223 C243 G244 Y245 L316 F317 S750 S1 T6 L8 C28 G29 Y30 L101 F102 S504 PDBbind-CN: Kd=0.1nM
BS02 dna B Y245 I263 Y264 S275 P277 R280 H284 S314 T737 V738 S739 T765 K766 R770 Y30 I48 Y49 S60 P62 R65 H69 S99 T491 V492 S493 T519 K520 R524 PDBbind-CN: Kd=0.1nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3thz, PDBe:3thz, PDBj:3thz
PDBsum3thz
PubMed22179786
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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