Structure of PDB 3thx Chain B

Receptor sequence
>3thxB (length=852) Species: 9606 (Homo sapiens) [Search protein sequence]
KSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCH
LDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSL
FSRKLTALYTKSTLIGEDVNPLIKLAVNVDEIMTDTSTSYLLCISENKNI
FIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQT
EALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAIVNLEKPVI
CSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQN
QTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEV
LHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKS
EFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKT
ELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQ
EFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLV
LDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPT
VQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMG
GKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTH
YPPVCELEKNYSHQVGNYHMGFLVSVTFLYQITRGIAARSYGLNVAKLAD
VPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFN
ME
3D structure
PDB3thx Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T221 P222 L223 C243 G244 Y245 H269 Q300 L316 F317 R319 T5 P6 L7 C27 G28 Y29 H53 Q84 L100 F101 R103 PDBbind-CN: Kd=70pM
BS02 dna B Y245 K246 I263 Y264 S275 P277 R280 H284 S314 S739 T765 K766 R770 Y29 K30 I47 Y48 S59 P61 R64 H68 S98 S498 T524 K525 R529 PDBbind-CN: Kd=70pM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3thx, PDBe:3thx, PDBj:3thx
PDBsum3thx
PubMed22179786
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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