Structure of PDB 3thw Chain B

Receptor sequence
>3thwB (length=860) Species: 9606 (Homo sapiens) [Search protein sequence]
SKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYC
HLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSS
LFSRKLTALYTKSTLIGEDVNPLIKLAVNVDEIMTDTSTSYLLCISENKE
NKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLP
SALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKG
IVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTT
LRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREIN
ARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLI
VKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNE
QAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPS
AQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRH
LNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVA
KQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERV
MIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGA
AGRSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEY
FIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVFVTFLYQITRGI
AARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTM
HNAQDLQKWT
3D structure
PDB3thw Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
ChainB
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T221 P222 L223 G244 Y245 I263 Y264 H266 H269 S275 H279 H284 Q300 R313 S314 L316 F317 V738 S739 T765 K766 R770 T6 P7 L8 G29 Y30 I48 Y49 H51 H54 S60 H64 H69 Q85 R98 S99 L101 F102 V506 S507 T533 K534 R538 PDBbind-CN: Kd=50pM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3thw, PDBe:3thw, PDBj:3thw
PDBsum3thw
PubMed22179786
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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