Structure of PDB 3tho Chain B

Receptor sequence
>3thoB (length=366) Species: 2336 (Thermotoga maritima) [Search protein sequence]
MKILHTSDWHLGVTSWTSSRPVDRREELKKALDKVVEEAEKREVDLILLT
GDLLHSRNNPSVVALHDLLDYLKRMMRTAPVVVLPGNQDWKGLKLFGNFV
TSISSDITFVMSFEPVDVEAKRGQKVRILPFPYPDESKNEGDFRFFLESR
LNKLYEEALKKEDFAIFMGHFTVEGLAGREIIINRALIPSVVDYAALGHI
HSFREIQKQPLTIYPGSLIRIDFGEEADEKGAVFVELKRGEPPRYERIDA
SPLPLKTLYYKKIDTSALKSIRDSCRNFPGYVRVVYEEDSGILPDLMGEI
DNLVKIERKSRREIEEVLRESPEEFKEELDKLDYFELFKEYLKKREENHE
KLLKILDELLDEVKKS
3D structure
PDB3tho ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.
ChainB
Resolution2.6081 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D14 H16 D58 H216 H218 D8 H10 D52 H199 H201
BS02 MN B D58 N93 H180 H216 D52 N87 H170 H199
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:3tho, PDBe:3tho, PDBj:3tho
PDBsum3tho
PubMed21937514
UniProtQ9X1X0|MRE11_THEMA DNA double-strand break repair protein Mre11 (Gene Name=mre11)

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