Structure of PDB 3tb3 Chain B

Receptor sequence
>3tb3B (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
EWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLF
KWQPGEEPAGSVVQDSRLDTIFFAKQVINNAAATQAIVSVLLNCTHQDVH
LGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARAFHFVSYVPVN
GRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMA
IVSD
3D structure
PDB3tb3 Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q82 A88 H164 D179
Catalytic site (residue number reindexed from 1) Q76 A82 H142 D157
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E109 E113 E103 E107
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0070628 proteasome binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
Cellular Component
GO:0031011 Ino80 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3tb3, PDBe:3tb3, PDBj:3tb3
PDBsum3tb3
PubMed21851340
UniProtQ9Y5K5|UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Gene Name=UCHL5)

[Back to BioLiP]