Structure of PDB 3t8s Chain B

Receptor sequence
>3t8sB (length=482) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDC
LFKLCPMNRYSAQKQFWKTTDAVLLNKLHHAADLEKKQNETENRKLLGTV
IQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQ
PFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNC
NTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFL
RTTSATSSKALWEVEVVQHDPWNSLFRFKHLATGHYLAAEVDYSLVSVPE
GNDISSIFELDPLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKI
GTSPLKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQN
ERRSVTKLLEDLVYFVTGEVVFSKPNRERQKLMREQNILKQIFKLLQAPP
FRHICRLCYRVLRHSQQDYRKNQEYIAKQFGF
3D structure
PDB3t8s Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor.
ChainB
Resolution3.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3P B R265 T267 Y567 R568 R251 T253 Y469 R470 PDBbind-CN: -logKd/Ki=8.55,Kd=2.82nM
BindingDB: Kd=8.7nM,EC50=209nM
Gene Ontology
Molecular Function
GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006816 calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3t8s, PDBe:3t8s, PDBj:3t8s
PDBsum3t8s
PubMed21892169
UniProtP29994|ITPR1_RAT Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (Gene Name=Itpr1)

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