Structure of PDB 3t8a Chain B

Receptor sequence
>3t8aB (length=274) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
LSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPH
TVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRRLHILE
VQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADV
GSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAE
LETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYM
TDEAVEGRDAFLRPPDWSPFPRYF
3D structure
PDB3t8a Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member.
ChainB
Resolution2.245 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 H135 G161 S164 D185 S190 D192 G193 A279 Y287
Catalytic site (residue number reindexed from 1) G91 H97 G123 S126 D147 S152 D154 G155 A241 Y249
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S0N B V57 R58 K95 S103 G105 D106 Q107 W157 V43 R44 K81 S89 G91 D92 Q93 W119
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:3t8a, PDBe:3t8a, PDBj:3t8a
PDBsum3t8a
PubMed21830810
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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