Structure of PDB 3t6y Chain B

Receptor sequence
>3t6yB (length=137) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
MHLKIVCLSDEVREMYKNHGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIA
LQYKSNYYYKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIA
ALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEEL
3D structure
PDB3t6y Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S27 R91 S93 L99 D109
Catalytic site (residue number reindexed from 1) S22 R73 S75 L81 D91
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K96 T97 P98 K78 T79 P80
BS02 DU2 B F46 N103 G106 I108 Y112 I116 I117 F41 N85 G88 I90 Y94 I98 I99 PDBbind-CN: -logKd/Ki=5.52,Ki=3.0uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0006260 DNA replication
GO:0006399 tRNA metabolic process
GO:0009117 nucleotide metabolic process
GO:0046081 dUTP catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3t6y, PDBe:3t6y, PDBj:3t6y
PDBsum3t6y
PubMed22049550
UniProtQ8II92

[Back to BioLiP]