Structure of PDB 3t6r Chain B

Receptor sequence
>3t6rB (length=68) Species: 9606 (Homo sapiens) [Search protein sequence]
EFGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLD
PPLSSVPSEDEWYCPECR
3D structure
PDB3t6r UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B P327 Q330 L331 M332 C333 D334 D337 E355 P31 Q34 L35 M36 C37 D38 D41 E59
BS02 ZN B C302 C305 C313 C316 C6 C9 C17 C20
BS03 ZN B C318 C321 H341 C344 C22 C25 H45 C48
BS04 ZN B C333 C336 C360 C363 C37 C40 C64 C67
BS05 ZN B H319 E362 H23 E66
External links
PDB RCSB:3t6r, PDBe:3t6r, PDBj:3t6r
PDBsum3t6r
PubMed22100450
UniProtQ96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Gene Name=UHRF1)

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