Structure of PDB 3sys Chain B

Receptor sequence

>3sysB (length=374) Species: 287 (Pseudomonas aeruginosa)

GFLEDAKTDLVLRNYYFNRDFRDLVDEWAQGFILKFSSGYTPGTVGVGLD
AIGLFGVKLNSELLPLHDDGRAADNYGRVGVAAKLRVSASELKIGEMLPD
IPLLRYDDGRLLPQTFRGFAVVSRELPGLALQAGRFDAVSLRNSADMQDL
SAWSAPTQKSDGFNYAGAEYRFNRERTQLGLWHGQLEDVYRQSYANLLHK
QRVGDWTLGANLGLFVDRDDGAARAGEIDSHTVYGLFSAGIGLHTFYLGL
QKVGGDSGWQSVYGSSGRSMGNDMFNGNFTNADERSWQVRYDYDFVGLGW
PGLIGMVRYGHGSNATTKAGSGGKEWERDVELGYTVQSGPLARLNVRLNH
ASNRRSFNSDFDQTRLVVSYPLSW

3D structure

• PDB: 3sys Substrate Specificity within a Family of Outer Membrane Carboxylate Channels.
• Chain: B
• Resolution: 1.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	C8E	B	Y307 V323	Y291 V307
BS02	C8E	B	G62 L63	G53 L54
BS03	C8E	B	Y122 D124	Y106 D108
BS04	C8E	B	Y325 W342 R344	Y309 W326 R328
BS05	C8E	B	H260 Y307	H244 Y291
BS06	C8E	B	R94 D162 M163	R78 D146 M147
BS07	C8E	B	H215 L224 G225 F253	H199 L208 G209 F237
BS08	VNL	B	K44 F45 D59 A60 I61 M113	K35 F36 D50 A51 I52 M97
BS09	VNL	B	H327 K340 E341 W342 R370 R371	H311 K324 E325 W326 R354 R355

Gene Ontology

Molecular Function

• GO:0015288 porin activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3sys, PDBe:3sys, PDBj:3sys
• PDBsum: 3sys
• PubMed: 22272184
• UniProt: Q9HUR5