Structure of PDB 3sxx Chain B

Receptor sequence

>3sxxB (length=664)

AAPARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAYI
QWKEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQPI
LTVEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWG
TGKRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKV
SKHKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNFK
FHIGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQRK
HALDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVCI
HEEDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQ
DGAIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRID
PRIDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTNY
ESATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAPW
ASHSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDIL
FFHTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMTT
SEAKRAVFEGSCCG

3D structure

• PDB: 3sxx The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with CuI and CoII.
• Chain: B
• Resolution: 1.27 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y305 D319 Y405 H456 H458 H624
• Catalytic site (residue number reindexed from 1): Y290 D304 Y390 H441 H443 H609
• Enzyme Commision number: 1.4.3.21: primary-amine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO	B	Y405 H456 H458 H624	Y390 H441 H443 H609

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0008131 primary methylamine oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0052595 aliphatic amine oxidase activity

Biological Process

• GO:0009308 amine metabolic process

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:3sxx, PDBe:3sxx, PDBj:3sxx
• PDBsum: 3sxx
• PubMed: 22691777
• UniProt: P12807|AMO_PICAN Peroxisomal primary amine oxidase (Gene Name=AMO)