Structure of PDB 3sxr Chain B

Receptor sequence
>3sxrB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMELKREEITLLKELVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQT
MMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQL
LEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLD
DQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPY
DLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLL
SSIEPLRE
3D structure
PDB3sxr X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D536 A538 R540 N541 D554 T572
Catalytic site (residue number reindexed from 1) D123 A125 R127 N128 D141 T159
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 B L423 A443 K445 T489 Y491 I492 S493 G495 L543 F555 L16 A30 K32 T76 Y78 I79 S80 G82 L130 F142 BindingDB: Kd=1.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3sxr, PDBe:3sxr, PDBj:3sxr
PDBsum3sxr
PubMed21883956
UniProtP51813|BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (Gene Name=BMX)

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