Structure of PDB 3su4 Chain B

Receptor sequence
>3su4B (length=192) [Search protein sequence]
GSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVSTA
TQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPQ
GSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSA
GGPLLCPAGHAVGIFKAAVSTRGVAKAVDFIPVESLETTMRS
3D structure
PDB3su4 The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
ChainB
Resolution2.255 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H68 D92 G148 A150
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SU3 B Q1041 F1043 H1057 V1078 D1081 I1132 L1135 K1136 G1137 A1139 F1154 K1155 A1156 A1157 Q52 F54 H68 V89 D92 I143 L146 K147 G148 A150 F165 K166 A167 A168 MOAD: Ki=554nM
BS02 ZN B C1097 C1099 C1145 H1149 C108 C110 C156 H160
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3su4, PDBe:3su4, PDBj:3su4
PDBsum3su4
PubMed22910833
UniProtP26664|POLG_HCV1 Genome polyprotein

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