Structure of PDB 3so9 Chain B

Receptor sequence
>3so9B (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPIVTIKIGGQLKEALLNTGADDTVLEEVNLPGRWKPKLIGGI
GGFVKVRQYDQVPIEICGHKVIGTVLVGPTPTNVIGRNLMTQIGCTLNF
3D structure
PDB3so9 The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
ChainB
Resolution2.87 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N25 T26 G27
Catalytic site (residue number reindexed from 1) N25 T26 G27
Enzyme Commision number 3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 017 B N25 A28 D30 I47 I50 T82 N25 A28 D30 I47 I50 T82 PDBbind-CN: -logKd/Ki=8.56,IC50=2.76nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3so9, PDBe:3so9, PDBj:3so9
PDBsum3so9
PubMed21871444
UniProtQ000H7

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