Structure of PDB 3sls Chain B

Receptor sequence
>3slsB (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
MTLQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG
LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI
CMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV
KPSNILVNSRGEIKLCDFGVSGQLIDFVGTRSYMSPERLQGTYSVQSDIW
SMGLSLVEMAVGRYPIGSMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN
KCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ
3D structure
PDB3sls Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 S194 N195 D208 D217 T226
Catalytic site (residue number reindexed from 1) D149 K151 S153 N154 D167 D176 T180
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B L74 G75 A76 G80 V82 A95 K97 M143 M146 S150 Q153 D190 K192 S194 N195 L197 D208 L33 G34 A35 G39 V41 A54 K56 M102 M105 S109 Q112 D149 K151 S153 N154 L156 D167
BS02 MG B N195 D208 N154 D167
BS03 77D B N78 K97 V127 I141 M143 D208 F209 G210 V211 S212 N37 K56 V86 I100 M102 D167 F168 G169 V170 S171 BindingDB: IC50=22nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3sls, PDBe:3sls, PDBj:3sls
PDBsum3sls
PubMed22245778
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

[Back to BioLiP]