Structure of PDB 3slh Chain B

Receptor sequence

>3slhB (length=439) Species: 227377 (Coxiella burnetii RSA 493) [Search protein sequence]

AMDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADN
LAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIR
LLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLK
IYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTER
LLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPG
SAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHAR
LKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAA
MVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLA
KGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGRGGF

3D structure

PDB

3slh 1.70 Angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase(AroA) from Coxiella burnetii in complex with shikimate-3-phosphate and glyphosate

Chain

Resolution

1.7 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	K21 S22 D48 N93 R123 D315 E343 H386 R387 T413
Catalytic site (residue number reindexed from 1)	K22 S23 D49 N94 R124 D316 E344 H387 R388 T414
Enzyme Commision number	2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	S3P	B	S22 R26 S167 A168 Q169 R194 D315 K342	S23 R27 S168 A169 Q170 R195 D316 K343
BS02	GPJ	B	K21 G95 T96 R123 Q169 D315 E343 R346 H386 R387	K22 G96 T97 R124 Q170 D316 E344 R347 H387 R388
BS03	SKM	B	S22 R26 Q169 R194 D315 K342	S23 R27 Q170 R195 D316 K343
BS04	GPJ	B	G36 Q37 N226 D227	G37 Q38 N227 D228

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0003866	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0016740	transferase activity
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups

	Biological Process
GO:0008652	amino acid biosynthetic process
GO:0009073	aromatic amino acid family biosynthetic process
GO:0009423	chorismate biosynthetic process

	Cellular Component
GO:0005737	cytoplasm

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3slh, PDBe:3slh, PDBj:3slh
PDBsum	3slh
PubMed
UniProt	Q83E11\|AROA_COXBU 3-phosphoshikimate 1-carboxyvinyltransferase (Gene Name=aroA)

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