Structure of PDB 3si7 Chain B

Receptor sequence
>3si7B (length=266) Species: 10090 (Mus musculus) [Search protein sequence]
TTGIIMENVTAFWEEGFGELLEKVQSFSHLCLVGNPVLKNINLNIEKGEM
LAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIK
ENIIGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRA
RISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVT
SKMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFT
EERRSSILTETLRRFS
3D structure
PDB3si7 Requirements for efficient correction of DeltaF508 CFTR revealed by analyses of evolved sequences
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B W401 Q413 T460 G461 G463 K464 T465 S466 W13 Q25 T57 G58 G60 K61 T62 S63
BS02 MG B Q413 T465 Q493 Q25 T62 Q90
BS03 MG B G451 A596 G48 A192
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3si7, PDBe:3si7, PDBj:3si7
PDBsum3si7
PubMed22265409
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

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