Structure of PDB 3sh7 Chain B

Receptor sequence
>3sh7B (length=255) Species: 1402 (Bacillus licheniformis) [Search protein sequence]
DFAKLEEQFDAKLGIFALDTGTNRTVAYRPDERFAFASTIKALTVGVLLQ
QKSIEDLNQRITYTRDDLVNYNPITEKHVDTGMTLKELADASLRYSDNAA
QNLILKQIGGPESLKKELRKIGDEVTNPERFCPELNEVNPGETQDTSTAR
ALVTSLRAFALEDKLPSEKRELLIDWMKRNTTGDALIRAGVPDGWEVADK
TGAASYGTRNDIAIIWPPKGDPVVLAVLSSRDKKDAKYDDKLIAEATKVV
MKALN
3D structure
PDB3sh7 Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 C166 K234 A237
Catalytic site (residue number reindexed from 1) S38 K41 S96 C132 K200 A203
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BB0 B N104 C166 L169 N70 C132 L135
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:3sh7, PDBe:3sh7, PDBj:3sh7
PDBsum3sh7
PubMed21705325
UniProtP00808|BLAC_BACLI Beta-lactamase (Gene Name=penP)

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