Structure of PDB 3sah Chain B

Receptor sequence
>3sahB (length=382) Species: 9606 (Homo sapiens) [Search protein sequence]
SIIRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERREQDMFAH
PYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVELNEKLLN
CQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESL
TDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHL
LKLYCNVDSNKQYQLADWRIRPLPEEMLSAARDDTHYLLYIYDKMRLEMW
ERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQ
LTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCN
PVPPLVRQQINEMHLLIQQAREMPLLKSEVAA
3D structure
PDB3sah Activities of human RRP6 and structure of the human RRP6 catalytic domain.
ChainB
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D313 E315 D371 A436 D440
Catalytic site (residue number reindexed from 1) D107 E109 D165 A230 D234
Enzyme Commision number 3.1.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D313 L314 D371 D107 L108 D165
BS02 MG B E315 D440 E109 D234
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006139 nucleobase-containing compound metabolic process
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3sah, PDBe:3sah, PDBj:3sah
PDBsum3sah
PubMed21705430
UniProtQ01780|EXOSX_HUMAN Exosome complex component 10 (Gene Name=EXOSC10)

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