Structure of PDB 3s95 Chain B

Receptor sequence
>3s95B (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
SMPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET
QRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKS
MDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVA
DFGLARLMVYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVN
ADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSF
VKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGES
3D structure
PDB3s95 Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
ChainB
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D460 N462 H464 N465 D478 N512
Catalytic site (residue number reindexed from 1) D133 N135 H137 N138 D151 N165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU B L345 G346 A353 V366 K368 E384 L397 T413 E414 Y415 I416 G419 H464 L467 L18 G19 A26 V39 K41 E57 L70 T86 E87 Y88 I89 G92 H137 L140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3s95, PDBe:3s95, PDBj:3s95
PDBsum3s95
PubMed
UniProtP53667|LIMK1_HUMAN LIM domain kinase 1 (Gene Name=LIMK1)

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