Structure of PDB 3s53 Chain B

Receptor sequence
>3s53B (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPLVTIKIGGQLKEALLDTGADDTIIEEMSLPGRWKPKMVGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPINIIGRNLLTQIGATLNF
3D structure
PDB3s53 Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
ChainB
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 017 B D25 A28 D30 I32 P81 D25 A28 D30 I32 P81 MOAD: Ki=0.23nM
PDBbind-CN: -logKd/Ki=9.64,Ki=0.23nM
BS02 017 B W42 P44 K55 V56 R57 V77 W42 P44 K55 V56 R57 V77 MOAD: Ki=0.23nM
PDBbind-CN: -logKd/Ki=9.64,Ki=0.23nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3s53, PDBe:3s53, PDBj:3s53
PDBsum3s53
PubMed22238126
UniProtQ7SSI0

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